Estrogen receptor β regulates the tumoral suppressor PTEN to modulate pituitary cell growth
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DOI: 10.1002/jcp.26025
Abstract: In this study, we focused on ERβ regulation in the adenohypophysis under different estrogenic milieu, by analyzing whether ER modulates the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression and its subcellular localization… read more here.
Keywords: pten; pituitary cell; modulate pituitary; tumoral suppressor ... See more keywords
The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
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DOI: 10.1016/j.isci.2021.102438
Abstract: Summary Tumor suppressor PTEN, the second most highly mutated protein in cancer, dephosphorylates signaling lipid PIP3 produced by PI3Ks. Excess PIP3 promotes cell proliferation. The mechanism at the membrane of this pivotal phosphatase is unknown… read more here.
Keywords: tumor suppressor; suppressor pten; membrane; mechanism ... See more keywords
Tumour suppressor PTEN activity is differentially inducible by myo‐inositol phosphates
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17699
Abstract: Tumour evolution and efficacy of treatments are controlled by the microenvironment, the composition of which is primarily dependent on the angiogenic reaction to hypoxic stress. Tumour angiogenesis normalization is a challenge for adjuvant therapy strategies… read more here.
Keywords: suppressor pten; myo inositol; pten activity; activity ... See more keywords