Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments.
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DOI: 10.1016/j.molcel.2018.08.027
Abstract: Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast, and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and localizes to nuclear speckles. Although cancer-associated mutations in… read more here.
Keywords: suppressor spop; tumor suppressor; mutations tumor; cancer ... See more keywords