Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22250
Abstract: The suprachiasmatic nucleus (SCN) is the most important circadian clock in mammals. The SCN synchronizes to environmental light via the retinohypothalamic tract (RHT), which is an axon cluster derived from melanopsinâexpressing intrinsic photosensitive retinal ganglion… read more here.
Keywords: vglut2; expression; vglut2 glun2b; suprachiasmatic nucleus ... See more keywords
Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling
Sign Up to like & getrecommendations! Published in 2022 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101533
Abstract: Circadian rhythms are 24-hour natural rhythms regulated by the suprachiasmatic nucleus, also known as the "master clock". The retino-hypothalamic tract entrains suprachiasmatic nucleus with photic information to synchronise endogenous circadian rhythms with the Earth's light-dark… read more here.
Keywords: alzheimer disease; suprachiasmatic nucleus; circadian rhythms; clock ... See more keywords
Expression profiles and functional annotation analysis of mRNAs in suprachiasmatic nucleus of Clock mutant mice.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.12.056
Abstract: The core circadian clock gene, Clock, is a positive component of the transcription/translation feedback loop in the master pacemaker suprachiasmatic nucleus (SCN) in mammals. The robust daytime peak of some clock genes in the wild-type… read more here.
Keywords: mutant mice; clock mutant; clock; suprachiasmatic nucleus ... See more keywords
Development of serotonergic projections to the suprachiasmatic nucleus in the mouse brain
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135438
Abstract: Serotonin (5-HT) and its innervation have been implicated in various neural functions including circadian systems. Although classical studies have examined the 5-HT innervation pattern in the adult suprachiasmatic nucleus (SCN), the fine-grained morphological study of… read more here.
Keywords: projections suprachiasmatic; development serotonergic; suprachiasmatic nucleus; brain ... See more keywords
Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.07.012
Abstract: The suprachiasmatic nucleus (SCN) acts as a master pacemaker driving circadian behavior and physiology. Although the SCN is small, it is composed of many cell types, making it difficult to study the roles of particular… read more here.
Keywords: color; cell; network synchrony; suprachiasmatic nucleus ... See more keywords
Reduction in vasopressin cells in the suprachiasmatic nucleus in mice increases anxiety and alters fluid intake
Sign Up to like & getrecommendations! Published in 2021 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2021.104997
Abstract: Central vasopressin (AVP) has been implicated in the control of multiple behaviors, including social behavior, anxiety-like behavior, and sickness behavior. The extent to which the different AVP-producing cell groups contribute to regulating these behaviors has… read more here.
Keywords: fluid intake; cells suprachiasmatic; anxiety; anxiety like ... See more keywords
The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17110-x
Abstract: The hypothalamic suprachiasmatic nuclei (SCN) are the principal mammalian circadian timekeeper, co-ordinating organism-wide daily and seasonal rhythms. To achieve this, cell-autonomous circadian timing by the ~20,000 SCN cells is welded into a tight circuit-wide ensemble… read more here.
Keywords: vip; circuit; vip vpac2; suprachiasmatic nucleus ... See more keywords
Generation of circadian rhythms in the suprachiasmatic nucleus
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-018-0026-z
Abstract: The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering only about 10,000 neurons on each side of the third ventricle, the SCN is our principal circadian clock, directing the daily cycles of behaviour… read more here.
Keywords: circadian rhythms; scn; physiology; generation circadian ... See more keywords
The Na+/H+-Exchanger NHE1 Regulates Extra- and Intracellular pH and Nimodipine-sensitive [Ca2+]i in the Suprachiasmatic Nucleus
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42872-w
Abstract: The central clock in the suprachiasmatic nucleus (SCN) has higher metabolic activity than extra-SCN areas in the anterior hypothalamus. Here we investigated whether the Na+/H+ exchanger (NHE) may regulate extracellular pH (pHe), intracellular pH (pHi)… read more here.
Keywords: exchanger; scn; sensitive ca2; ca2 ... See more keywords
Cryptochrome 1 as a state variable of the circadian clockwork of the suprachiasmatic nucleus: Evidence from translational switching
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203563119
Abstract: Significance Circadian clocks adapt us to our rhythmic world, setting the tempo to our lives. Their disruption (e.g., by shiftwork) therefore carries a severe cost in health. The suprachiasmatic nucleus (SCN) is the principal brain… read more here.
Keywords: state variable; translational switching; cryptochrome state; clockwork ... See more keywords
Aging of the Suprachiasmatic Nucleus, CIRCLONSA syndrome, implications for regenerative medicine and restoration of the master body clock.
Sign Up to like & getrecommendations! Published in 2021 at "Rejuvenation research"
DOI: 10.1089/rej.2020.2388
Abstract: The suprachiasmatic nucleus (SCN) in the brain is the master regulator of the circadian clocks throughout the human body. With increasing age the circadian clock in humans and other mammals becomes increasingly disorganized leading to… read more here.
Keywords: master; medicine; circlonsa syndrome; suprachiasmatic nucleus ... See more keywords