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   Articles with "suprachiasmatic nucleus" as a keyword



Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus

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recommendations! Published in 2022 at "Synapse"

DOI: 10.1002/syn.22250

Abstract: The suprachiasmatic nucleus (SCN) is the most important circadian clock in mammals. The SCN synchronizes to environmental light via the retinohypothalamic tract (RHT), which is an axon cluster derived from melanopsin‐expressing intrinsic photosensitive retinal ganglion… read more here.

Keywords: vglut2; expression; vglut2 glun2b; suprachiasmatic nucleus ... See more keywords

Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling

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recommendations! Published in 2022 at "Ageing Research Reviews"

DOI: 10.1016/j.arr.2021.101533

Abstract: Circadian rhythms are 24-hour natural rhythms regulated by the suprachiasmatic nucleus, also known as the "master clock". The retino-hypothalamic tract entrains suprachiasmatic nucleus with photic information to synchronise endogenous circadian rhythms with the Earth's light-dark… read more here.

Keywords: alzheimer disease; suprachiasmatic nucleus; circadian rhythms; clock ... See more keywords

Expression profiles and functional annotation analysis of mRNAs in suprachiasmatic nucleus of Clock mutant mice.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2017.12.056

Abstract: The core circadian clock gene, Clock, is a positive component of the transcription/translation feedback loop in the master pacemaker suprachiasmatic nucleus (SCN) in mammals. The robust daytime peak of some clock genes in the wild-type… read more here.

Keywords: mutant mice; clock mutant; clock; suprachiasmatic nucleus ... See more keywords

Development of serotonergic projections to the suprachiasmatic nucleus in the mouse brain

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recommendations! Published in 2020 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2020.135438

Abstract: Serotonin (5-HT) and its innervation have been implicated in various neural functions including circadian systems. Although classical studies have examined the 5-HT innervation pattern in the adult suprachiasmatic nucleus (SCN), the fine-grained morphological study of… read more here.

Keywords: projections suprachiasmatic; development serotonergic; suprachiasmatic nucleus; brain ... See more keywords
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Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony

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recommendations! Published in 2020 at "Neuron"

DOI: 10.1016/j.neuron.2020.07.012

Abstract: The suprachiasmatic nucleus (SCN) acts as a master pacemaker driving circadian behavior and physiology. Although the SCN is small, it is composed of many cell types, making it difficult to study the roles of particular… read more here.

Keywords: color; cell; network synchrony; suprachiasmatic nucleus ... See more keywords
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Reduction in vasopressin cells in the suprachiasmatic nucleus in mice increases anxiety and alters fluid intake

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recommendations! Published in 2021 at "Hormones and Behavior"

DOI: 10.1016/j.yhbeh.2021.104997

Abstract: Central vasopressin (AVP) has been implicated in the control of multiple behaviors, including social behavior, anxiety-like behavior, and sickness behavior. The extent to which the different AVP-producing cell groups contribute to regulating these behaviors has… read more here.

Keywords: fluid intake; cells suprachiasmatic; anxiety; anxiety like ... See more keywords

Nighttime-specific differential gene expression in suprachiasmatic nucleus and habenula is associated with resilience to chronic social stress

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recommendations! Published in 2024 at "Translational Psychiatry"

DOI: 10.1038/s41398-024-03100-w

Abstract: The molecular mechanisms that link stress and biological rhythms still remain unclear. The habenula (Hb) is a key brain region involved in regulating diverse types of emotion-related behaviours while the suprachiasmatic nucleus (SCN) is the… read more here.

Keywords: gene expression; stress; suprachiasmatic nucleus; expression ... See more keywords

System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning

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recommendations! Published in 2024 at "Cell Research"

DOI: 10.1038/s41422-024-00956-x

Abstract: The suprachiasmatic nucleus (SCN) is the mammalian central circadian pacemaker with heterogeneous neurons acting in concert while each neuron harbors a self-sustained molecular clockwork. Nevertheless, how system-level SCN signals encode time of the day remains… read more here.

Keywords: suprachiasmatic nucleus; machine learning; time; system level ... See more keywords

The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-17110-x

Abstract: The hypothalamic suprachiasmatic nuclei (SCN) are the principal mammalian circadian timekeeper, co-ordinating organism-wide daily and seasonal rhythms. To achieve this, cell-autonomous circadian timing by the ~20,000 SCN cells is welded into a tight circuit-wide ensemble… read more here.

Keywords: vip; circuit; vip vpac2; suprachiasmatic nucleus ... See more keywords

Discrete photoentrainment of mammalian central clock is regulated by bi-stable dynamic network in the suprachiasmatic nucleus

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-025-58661-1

Abstract: The circadian clock, an evolutionarily conserved mechanism regulating the majority of physiological functions in many organisms, is synchronized with the environmental light-dark cycle through circadian photoentrainment. This process is mediated by light exposure at specific… read more here.

Keywords: photoentrainment mammalian; suprachiasmatic nucleus; central clock; clock ... See more keywords

Generation of circadian rhythms in the suprachiasmatic nucleus

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recommendations! Published in 2018 at "Nature Reviews Neuroscience"

DOI: 10.1038/s41583-018-0026-z

Abstract: The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering only about 10,000 neurons on each side of the third ventricle, the SCN is our principal circadian clock, directing the daily cycles of behaviour… read more here.

Keywords: circadian rhythms; scn; physiology; generation circadian ... See more keywords