Isomer-driven supramolecular polymorphism of 4-hydroxytamoxifen modulating nanostructure-dependent cellular uptake and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d5nr02944a
Abstract: Geometric isomerism in small-molecule drugs has traditionally been studied in the context of receptor binding or metabolic stability. However, its influence on supramolecular behavior and downstream biological function remains underexplored. Here, we investigate how the… read more here.
Keywords: supramolecular polymorphism; cytotoxicity; isomer; isomer driven ... See more keywords
Supramolecular Polymorphism of (G4C2)n Repeats Associated with ALS and FTD
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094532
Abstract: Guanine-rich DNA sequences self-assemble into highly stable fourfold structures known as DNA-quadruplexes (or G-quadruplexes). G-quadruplexes have furthermore the tendency to associate into one-dimensional supramolecular aggregates termed G-wires. We studied the formation of G-wires in solutions… read more here.
Keywords: g4c2 formed; g4c2; g4c2 repeats; supramolecular polymorphism ... See more keywords