Multifunctional Supramolecular Vesicles as Zn2+ -Triggered Microglial Modulator Alleviates Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202302176
Abstract: Zn2+ -induced β-amyloid protein (Aβ) aggregation and microglia activation are the predominant contributors in Alzheimer's disease (AD). Regulating intracephalic excessive Zn2+ is a promising therapeutic strategy for AD treatment. However, only inhibition of Zn2+ is… read more here.
Keywords: supramolecular vesicles; alzheimer disease; loaded vesicles; res loaded ... See more keywords
Smart supramolecular vesicles based on glutathione-reactive pillar[6]arene and acid-labile prodrug: Dual drug loading and sequential release
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.07.024
Abstract: Abstract Glutathione thiol-reactive pillar[6]arene (TWP6) is designed and synthesized as the first example of reducing agent-reactive host molecule. TWP6 shows high affinity binding towards suitable anti-tumor drugs and guests. Doxorubicin-based acid-labile prodrugs and TWP6 are… read more here.
Keywords: reactive pillar; sequential release; pillar arene; acid labile ... See more keywords