Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
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DOI: 10.1093/glycob/cwac035
Abstract: Mannosyl phosphorylceramide (MIPC) is a membrane lipid classified as a complex sphingolipid in Saccharomyces cerevisiae. MIPC is synthesized by two redundant enzymes, Sur1/Csg1 and Csh1, in the Golgi lumen. MIPC consists of five subtypes (A,… read more here.
Keywords: pleiotropic roles; roles glycans; sur1 csg1; sur1 ... See more keywords
SUR1 as a New Therapeutic Target for Pulmonary Arterial Hypertension.
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DOI: 10.1165/rcmb.2021-0180oc
Abstract: Mutations in ABCC8 have been identified in pulmonary arterial hypertension (PAH). ABCC8 encodes SUR1, a regulatory subunit of the ATP-sensitive-potassium channel Kir6.2. However, the pathophysiological role of the SUR1/Kir6.2 channel in PAH is unknown. We… read more here.
Keywords: activation sur1; hypertension; pulmonary arterial; sur1 kir6 ... See more keywords
Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice
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DOI: 10.12688/wellcomeopenres.15529.2
Abstract: Background: The K ATP channel plays a key role in glucose homeostasis by coupling metabolically generated changes in ATP to insulin secretion from pancreatic beta-cells. Gain-of-function mutations in either the pore-forming (Kir6.2) or regulatory (SUR1)… read more here.
Keywords: phenotype; sur1; mice; sur1 r1183w ... See more keywords