SUR1 as a New Therapeutic Target for Pulmonary Arterial Hypertension.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0180oc
Abstract: Mutations in ABCC8 have been identified in pulmonary arterial hypertension (PAH). ABCC8 encodes SUR1, a regulatory subunit of the ATP-sensitive-potassium channel Kir6.2. However, the pathophysiological role of the SUR1/Kir6.2 channel in PAH is unknown. We… read more here.
Keywords: activation sur1; hypertension; pulmonary arterial; sur1 kir6 ... See more keywords
SUR1/Kir6.2 potassium channel a new actor involved in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2020.3561
Abstract: Background: Recently mutations in ABBC8 have been identified in patients with pulmonary arterial hypertension (PAH). ABCC8 encodes SUR1 a regulatory subunit of the ATP-sensitive potassium channel Kir6.2. In 2018, Bohnen M et al., demonstrated that… read more here.
Keywords: kir6; pulmonary arterial; sur1 kir6; hypertension ... See more keywords