1673-P: Canagliflozin Accelerates Fasting Hypoglycemia in Sur1 Knockout Mice by Elevating GLP-1 Secretion
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DOI: 10.2337/db25-1673-p
Abstract: Introduction and Objective: SUR1 knockout (SUR1-/-) mice serve as a hyperinsulinism model characterized by persistent beta-cell depolarization with fasting hypoglycemia, unresponsive to glucose-stimulated insulin secretion with impaired glucose tolerance, increased sensitivity to GLP-1 amplification of… read more here.
Keywords: sur1 mice; mice; canagliflozin; glp secretion ... See more keywords