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   Articles with "sur1 trpm4" as a keyword



Serum SUR1 and TRPM4 in patients with subarachnoid hemorrhage

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recommendations! Published in 2019 at "Neurosurgical Review"

DOI: 10.1007/s10143-019-01200-6

Abstract: Neuroinflammation plays an important role in neuronal injury after aneurysmal subarachnoid hemorrhage (aSAH). Sulfonylurea receptor 1 (SUR1) and transient receptor potential cation channel subfamily M member 4 (TRPM4) receptors play an important role in the… read more here.

Keywords: trpm4 levels; serum sur1; sur1 trpm4; trpm4 ... See more keywords

Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion

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recommendations! Published in 2019 at "Journal of Neurotrauma"

DOI: 10.1089/neu.2018.5986

Abstract: Abstract In severe traumatic brain injury (TBI), contusions often are worsened by contusion expansion or hemorrhagic progression of contusion (HPC), which may double the original contusion volume and worsen outcome. In humans and rodents with… read more here.

Keywords: trpm4; contusion; kir6; sur1 trpm4 ... See more keywords

Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis

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recommendations! Published in 2017 at "Journal of Neuroinflammation"

DOI: 10.1186/s12974-017-0953-z

Abstract: BackgroundIn multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), inflammation is perpetuated by both infiltrating leukocytes and astrocytes. Recent work implicated SUR1-TRPM4 channels, expressed mostly by astrocytes, in murine EAE. We tested the hypothesis that… read more here.

Keywords: trpm4; chronic phase; autoimmune encephalomyelitis; sur1 trpm4 ... See more keywords

Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date

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recommendations! Published in 2018 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s150043

Abstract: Glyburide (also known as glibenclamide) is a second-generation sulfonylurea drug that inhibits sulfonylurea receptor 1 (Sur1) at nanomolar concentrations. Long used to target KATP (Sur1–Kir6.2) channels for the treatment of diabetes mellitus type 2, glyburide… read more here.

Keywords: trpm4; large hemispheric; glyburide; edema ... See more keywords