Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virological Methods"
DOI: 10.1016/j.jviromet.2021.114283
Abstract: The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in… read more here.
Keywords: cov rna; rna dependent; rna polymerase; suramin ... See more keywords
Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42902
Abstract: Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. Here, we identify VP1-145 as the critical amino acid that accounts for… read more here.
Keywords: a71 capsid; region surrounding; suramin; charged region ... See more keywords
The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes
Sign Up to like & getrecommendations! Published in 2023 at "Microbial Cell"
DOI: 10.15698/mic2023.02.790
Abstract: The surface proteins of parasitic protozoa mediate functions essential to survival within a host, including nutrient accumulation, environmental sensing and immune evasion. Several receptors involved in nutrient uptake and defence from the innate immune response… read more here.
Keywords: suramin; invariant surface; african trypanosomes; surface ... See more keywords
Effects of Suramin on Polycystic Kidney Disease in a Mouse Model of Polycystin-1 Deficiency
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158499
Abstract: The aberrant activation of the purinergic signaling pathway has been shown to promote cyst growth and fluid secretion in autosomal dominant polycystic kidney disease (ADPKD). Suramin is an anti-parasitic drug that has strong anti-purinergic properties.… read more here.
Keywords: suramin; cyst; polycystic kidney; kidney disease ... See more keywords
Suramin Disturbs the Association of the N-Terminal Domain of SARS-CoV-2 Nucleocapsid Protein with RNA
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062534
Abstract: Suramin was originally used as an antiparasitic drug in clinics. Here, we demonstrate that suramin can bind to the N-terminal domain of SARS-CoV-2 nucleocapsid protein (N-NTD) and disturb its interaction with RNA. The BLI experiments… read more here.
Keywords: nucleocapsid protein; suramin; terminal domain; cov nucleocapsid ... See more keywords