Surf4 (Surfeit Locus Protein 4) Deficiency Reduces Intestinal Lipid Absorption and Secretion and Decreases Metabolism in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.123.318980
Abstract: Background: Postprandial dyslipidemia is a causative risk factor for cardiovascular disease. The majority of absorbed dietary lipids are packaged into chylomicron and then delivered to circulation. Previous studies showed that Surf4 (surfeit locus protein 4)… read more here.
Keywords: surf4; secretion; lipid absorption; surf4iko mice ... See more keywords
Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.82269
Abstract: PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor that… read more here.
Keywords: surf4fl alb; surf4; alb cre; mice ... See more keywords