Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52121-9
Abstract: Designed armadillo repeat proteins (dArmRPs) bind extended peptides in a modular way. The consensus version recognises alternating arginines and lysines, with one dipeptide per repeat. For generating new binding specificities, the rapid and robust analysis… read more here.
Keywords: binding surface; binding proteins; repeat; surface crystal ... See more keywords
Crystal structure determination, Hirshfeld surface, crystal void, intermolecular interaction energy analyses, as well as DFT and energy framework calculations of 2-(4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetic acid
Sign Up to like & getrecommendations! Published in 2022 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989022008489
Abstract: The bicyclic ring system is planar with the carboxymethyl group rotated out of this plane by 81.05 (5)°. In the crystal, corrugated layers are generated by N—H⋯O, O—H⋯N and C—H⋯O hydrogen-bonding interactions. The layers are associated… read more here.
Keywords: structure determination; energy; determination hirshfeld; surface crystal ... See more keywords