Expression of SARS-CoV-2 surface glycoprotein fragment 319–640 in E. coli, and its refolding and purification
Sign Up to like & getrecommendations! Published in 2021 at "Protein Expression and Purification"
DOI: 10.1016/j.pep.2021.105861
Abstract: Sensitive and specific serology tests are essential for epidemiological and public health studies of COVID-19 and for vaccine efficacy testing. The presence of antibodies to SARS-CoV-2 surface glycoprotein (Spike) and, specifically, its receptor-binding domain (RBD)… read more here.
Keywords: surface glycoprotein; serology; expression; cov surface ... See more keywords
Evolution of the variant surface glycoprotein family in African trypanosomes.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in parasitology"
DOI: 10.1016/j.pt.2021.07.012
Abstract: An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies… read more here.
Keywords: surface glycoprotein; variant surface; family; evolution variant ... See more keywords
Visual Electrofluorochromic Detection of Cancer Cell Surface Glycoprotein on a Closed Bipolar Electrode Chip.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b01760
Abstract: This work reports an electrofluorochromic strategy on the basis of electric field control of fluorescent signal generation on bipolar electrodes (BPEs) for visualizing cancer cell surface glycoprotein (mucin 1). The device included two separate cells:… read more here.
Keywords: detection; surface glycoprotein; cancer cell; cancer ... See more keywords
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10823-8
Abstract: The largest gene families in eukaryotes are subject to allelic exclusion, but mechanisms underpinning single allele selection and inheritance remain unclear. Here, we describe a protein complex sustaining variant surface glycoprotein (VSG) allelic exclusion and… read more here.
Keywords: surface glycoprotein; exclusion; inheritance; variant surface ... See more keywords
Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity.
Sign Up to like & getrecommendations! Published in 2020 at "NPJ vaccines"
DOI: 10.1038/s41541-020-00219-x
Abstract: Lassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease. To date, no therapeutics or vaccines against… read more here.
Keywords: surface glycoprotein; virus like; like particles; envelope surface ... See more keywords
Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat
Sign Up to like & getrecommendations! Published in 2017 at "Nature Microbiology"
DOI: 10.1038/s41564-017-0013-6
Abstract: The most prominent defence of the unicellular parasite Trypanosoma brucei against the host immune system is a dense coat that comprises a variant surface glycoprotein (VSG). Despite the importance of the VSG family, no complete… read more here.
Keywords: vsg; surface glycoprotein; surface; variant surface ... See more keywords
Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.13854
Abstract: Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei… read more here.
Keywords: surface glycoprotein; variant surface; trypanosoma brucei; suramin resistance ... See more keywords
Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03847-21
Abstract: The single-cell parasite Trypanosoma brucei causes the fatal disease human African trypanosomiasis and is able to colonize the blood, fat, skin, and central nervous system. Trypanosomes survive in the mammalian host owing to a dense… read more here.
Keywords: variant surface; surface glycoprotein; trypanosoma brucei; vsg ... See more keywords
Interaction of surface glycoprotein of SARS-CoV-2 variants of concern with potential drug candidates: A molecular docking study
Sign Up to like & getrecommendations! Published in 2022 at "F1000Research"
DOI: 10.12688/f1000research.109586.1
Abstract: Background: COVID-19 has become a global threat. Since its first outbreak from Wuhan, China in December 2019, the SARS-CoV-2 virus has gone through structural changes arising due to mutations in its surface glycoprotein. These mutations… read more here.
Keywords: drug; molecular docking; surface glycoprotein; binding energy ... See more keywords
The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes
Sign Up to like & getrecommendations! Published in 2023 at "Microbial Cell"
DOI: 10.15698/mic2023.02.790
Abstract: The surface proteins of parasitic protozoa mediate functions essential to survival within a host, including nutrient accumulation, environmental sensing and immune evasion. Several receptors involved in nutrient uptake and defence from the innate immune response… read more here.
Keywords: suramin; invariant surface; african trypanosomes; surface ... See more keywords