Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells
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DOI: 10.1002/eji.202149259
Abstract: Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its halfâlife. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells. Recent data… read more here.
Keywords: properdin binding; alternative pathway; necrotic cells; properdin ... See more keywords