Investigation of Polymer/Surfactant Interactions and Their Impact on Itraconazole Solubility and Precipitation Kinetics for Developing Spray-Dried Amorphous Solid Dispersions.
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DOI: 10.1021/acs.molpharmaceut.7b00902
Abstract: Methods were developed to systematically screen different polymer-surfactant combinations for the purpose of enhancing amorphous active pharmaceutical ingredient (API) solubility while maintaining its physical stability. Itraconazole (ITZ) was chosen as the model API mostly due… read more here.
Keywords: surfactant combinations; surfactant interactions; solubility; polymer surfactant ... See more keywords