Gene therapeutics for surfactant dysfunction disorders: Targeting the alveolar type 2 epithelial cell.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2022.130
Abstract: Genetic disorders of surfactant dysfunction result in significant morbidity and mortality, among infants, children, and adults. Available medical interventions are limited, non-specific and generally ineffective. As such, the need for effective therapies remains. Pathogenic variants… read more here.
Keywords: alveolar type; gene; surfactant dysfunction; gene therapeutics ... See more keywords
Surfactant Dysfunction in ARDS and Bronchiolitis is Repaired with Cyclodextrins.
Sign Up to like & getrecommendations! Published in 2018 at "Military medicine"
DOI: 10.1093/milmed/usx204
Abstract: Objectives Acute respiratory distress syndrome (ARDS) is caused by many factors including inhalation of toxicants, acute barotrauma, acid aspiration, and burns. Surfactant function is impaired in ARDS and acute airway injury resulting in high surface… read more here.
Keywords: bronchiolitis; surfactant dysfunction; bronchiolitis repaired; repaired cyclodextrins ... See more keywords