MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0478-3
Abstract: Proper regulation of epigenetic states of chromatin is crucial to achieve tissue-specific gene expression during embryogenesis. The lung-specific gene products, surfactant proteins B (SP-B) and C (SP-C), are synthesized in alveolar epithelial cells and prevent… read more here.
Keywords: ctbp; surfactant proteins; promotes expression; gene silencing ... See more keywords
Changes in membrane elasticity caused by the hydrophobic surfactant proteins correlate poorly with adsorption of lipid vesicles.
Sign Up to like & getrecommendations! Published in 2021 at "Soft matter"
DOI: 10.1039/d0sm02223c
Abstract: To establish how the hydrophobic surfactant proteins, SP-B and SP-C, promote adsorption of lipids to an air/water interface, we used X-ray diffuse scattering (XDS) to determine an order parameter of the lipid chains (Sxray) and… read more here.
Keywords: adsorption; hydrophobic surfactant; proteins produced; adsorption lipid ... See more keywords
Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein–Lipid Interactions
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DOI: 10.1101/2022.12.12.520108
Abstract: The lining of the alveoli is covered by pulmonary surfactant, a complex mixture of surface-active lipids and proteins that enables efficient gas exchange between inhaled air and the circulation. Despite decades of advancements in the… read more here.
Keywords: lipid interactions; microscopy; lipids proteins; surfactant proteins ... See more keywords
Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins
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DOI: 10.1159/000492974
Abstract: Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An… read more here.
Keywords: fusion proteins; immunity; surfactant proteins; viral fusion ... See more keywords
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202201-0011oc
Abstract: Rationale Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. Objectives To assess whether IgA autoantibodies target lung-specific… read more here.
Keywords: iga autoantibodies; severe covid; patients severe; surfactant proteins ... See more keywords
Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1118770
Abstract: Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart failure, and… read more here.
Keywords: inflammation; sigmar1; pulmonary fibrosis; surfactant proteins ... See more keywords
Changes in CSF Surface Tension in Relation to Surfactant Proteins in Children with Intraventricular Hemorrhage
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DOI: 10.3390/brainsci12111440
Abstract: The regulation of surface tension (ST) by surfactants plays an important role in the human respiratory system but is largely unexplored in brain homeostasis. The aim of this study was to evaluate changes in ST… read more here.
Keywords: intraventricular hemorrhage; ivh; surface tension; relation surfactant ... See more keywords