Prognostic significance of surgery-induced sarcopenia in the survival of gastric cancer patients: a sex-specific analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12793
Abstract: BACKGROUND Preoperative sarcopenia is associated with a poor long-term prognosis in patients with gastric cancer (GC). Most GC patients rapidly lose muscle mass after gastrectomy. This retrospective cohort study analysed the effect of postoperative muscle… read more here.
Keywords: surgery; muscle; surgery induced; induced sarcopenia ... See more keywords
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Cell Discovery"
DOI: 10.1038/s41421-022-00382-6
Abstract: Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-regeneration capacity of the tissue. In this study, we found that the expression of prostaglandin E receptor 4 (PTGER4 or EP4)… read more here.
Keywords: surgery induced; articular cartilage; prostaglandin receptor; cartilage ... See more keywords
Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of Natural Killer cell cytotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1431082
Abstract: ABSTRACT Cancer surgery while necessary for primary tumor removal, has been shown to induce immune suppression and promote metastases in preclinical models and human cancer surgery patients. Activating the immune system and reversing immunosuppression have… read more here.
Keywords: cancer surgery; surgery; inhibition; surgery induced ... See more keywords
Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab022
Abstract: In clinic, perioperative neurocognitive disorder is becoming a common complication of surgery in old patients. Neuroinflammation and blood-brain barrier (BBB) disruption are important contributors for cognitive impairment. Atorvastatin, as a strong HMG-CoA reductase inhibitor, has… read more here.
Keywords: surgery; atorvastatin; surgery induced; cognitive impairment ... See more keywords
179: METABOLOMIC FINGERPRINTING IN A PIGLET MODEL OF INFANT CARDIAC SURGERY-INDUCED ACUTE KIDNEY INJURY
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000619076.92191.53
Abstract: Introduction/Hypothesis: The pathologic tissue and urine metabolic fingerprints of cardiac surgery-induced acute kidney injury (AKI) have not been well defined. In this study, we utilized a porcine model of infant cardiopulmonary bypass (CPB) with deep… read more here.
Keywords: surgery induced; tissue; dhca; cardiac surgery ... See more keywords
Vitamin D3 Supplementation Attenuates Surgery-Induced Neuroinflammation and Cognitive Impairment by Regulating NLRP3 Inflammasome in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/4696415
Abstract: Neuroinflammation plays a dominant role in the progression of postoperative cognitive dysfunction (POCD). Vitamin D has been known to have important regulatory functions in inflammation and immune response. The NOD-like receptor protein 3 (NLRP3) is… read more here.
Keywords: neuroinflammation; surgery; cognitive impairment; surgery induced ... See more keywords
Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0336
Abstract: Data from patients and a mouse model show that surgery for bladder cancer causes immune dysfunction and decreases efficacy of immunotherapy. Low-dose rapamycin mitigated these problems through effects on the tumor and through modulating T-cell… read more here.
Keywords: cancer; bladder cancer; rapamycin; surgery induced ... See more keywords
Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0913-7
Abstract: BackgroundNeuroinflammation plays a major role in postoperative cognitive dysfunction (POCD). Accumulated evidence indicates that cannabinoid receptor type 2 (CB2R) can mediate anti-inflammatory and immunomodulatory effects in part by controlling microglial activity. However, the impact of… read more here.
Keywords: surgery; surgery induced; mice; cb2r ... See more keywords
The Effect of SIRT3/Ac-SOD2 Mediated Oxidative Stress and HCN1 Channel Activity on Anesthesia/Surgery Induced Anxiety-Like Behavior in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.783931
Abstract: Anxiety disorders are the most common psychiatric diseases, and perioperative factors often increase the incidence of anxiety. However, the mechanism and treatment for perioperative anxiety, especially anesthesia/surgery-induced postoperative anxiety, are largely unknown. Sirtuin 3 (SIRT3)… read more here.
Keywords: surgery induced; anxiety; anesthesia surgery; oxidative stress ... See more keywords
Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.996223
Abstract: We investigated the protective effect of young plasma on anesthesia- and surgery-induced cognitive impairment and the potential underlying mechanism using bioinformatics, functional enrichment analysis, gene set enrichment analysis, Golgi-Cox staining, dendritic spine analysis, immunofluorescence assay,… read more here.
Keywords: induced cognitive; young plasma; cognitive impairment; surgery induced ... See more keywords
Nobiletin Attenuates Anesthesia/Surgery-Induced Neurocognitive Decline by Preserving the Expression of Clock Genes in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.938874
Abstract: Postoperative cognitive dysfunction (POCD) is commonly observed during the postoperative period and significantly affects the prognosis of patients. Neuroinflammation plays a vital role in the pathogenesis of POCD. Despite laboratory and clinical research over the… read more here.
Keywords: decline; preserving expression; pocd; expression ... See more keywords