Use of Placebo and Nonoperative Control Groups in Surgical Trials
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DOI: 10.1001/jamanetworkopen.2022.23903
Abstract: This systematic review and meta-analysis estimates the proportion of the observed effect of surgical treatment due to nonspecific effects, including the placebo effect. read more here.
Keywords: use placebo; groups surgical; control groups; nonoperative control ... See more keywords
Recruitment and retention of participants in UK surgical trials: survey of key issues reported by trial staff
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DOI: 10.1002/bjs5.50345
Abstract: Recruitment and retention of participants in surgical trials is challenging. Knowledge of the most common and problematic issues will aid future trial design. This study aimed to identify trial staff perspectives on the main issues… read more here.
Keywords: trial; recruitment retention; retention participants; surgical trials ... See more keywords
Evidence-based recommendations for blinding in surgical trials
Sign Up to like & getrecommendations! Published in 2019 at "Langenbeck's Archives of Surgery"
DOI: 10.1007/s00423-019-01761-6
Abstract: RationaleBlinding reduces performance and detection bias in randomized controlled trials (RCT). There is evidence that lack of blinding leads to overestimation of treatment effects in pharmacological trials. Since surgical trials use interventions with a physical… read more here.
Keywords: based recommendations; study; evidence; blinding surgical ... See more keywords
Comment on: Recruitment and retention of participants in UK surgical trials: survey of key issues reported by trial staff
Sign Up to like & getrecommendations! Published in 2021 at "BJS Open"
DOI: 10.1093/bjsopen/zrab110
Abstract: Crocker et al. have highlighted an important issue faced by institutions running surgical trials. Recruitment challenges can prevent trials from running, rendering all the time and expertise taken to design the trial fruitless. There has… read more here.
Keywords: recruitment retention; trial; survey; surgical trials ... See more keywords