Identification of peptide sequences that selectively bind to pentaerythritol trinitrate hemisuccinate‐a surrogate of PETN, via phage display technology
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.22997
Abstract: The present research investigates the identification of amino acid sequences that selectively bind to a pentaerythritol tetranitrate (PETN) explosive surrogate. Through the use of a phage display technique and enzyme‐linked immunosorbent assays (ELISA), a peptide… read more here.
Keywords: sequences selectively; phage display; petn; surrogate ... See more keywords
Surrogate‐based Bayesian calibration of biomechanical models with isotropic material behavior
Sign Up to like & getrecommendations! Published in 2022 at "International Journal for Numerical Methods in Biomedical Engineering"
DOI: 10.1002/cnm.3575
Abstract: This work introduces a computational methodology to calibrate material models in biomechanical applications under uncertainty. We adopt a Bayesian approach, which estimates the probability distributions of hyperelastic material parameters, based on force‐strain measurements. We approximate… read more here.
Keywords: bayesian calibration; surrogate based; methodology; based bayesian ... See more keywords
Identification of surrogate prognostic biomarkers for allergic asthma in nasal epithelial brushing samples by WGCNA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27790
Abstract: Allergic asthma is a lower respiratory tract disease of Th2 inflammation with multiple molecular mechanisms. The upper and lower airways can be unified by the concept of a united airway and, as such, gene expression… read more here.
Keywords: prognostic biomarkers; surrogate; identification surrogate; biomarkers allergic ... See more keywords
Validation of surrogate endpoints in cancer clinical trials via principal stratification with an application to a prostate cancer trial.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7318
Abstract: Increasing attention has been focused on the use and validation of surrogate endpoints in cancer clinical trials. Previous literature on validation of surrogate endpoints are classified into four approaches: the proportion explained approach; the indirect… read more here.
Keywords: surrogate endpoints; surrogate; endpoints cancer; validation surrogate ... See more keywords
Incorporating baseline covariates to validate surrogate endpoints with a constant biomarker under control arm.
Sign Up to like & getrecommendations! Published in 2021 at "Statistics in medicine"
DOI: 10.1002/sim.9201
Abstract: A surrogate endpoint S in a clinical trial is an outcome that may be measured earlier or more easily than the true outcome of interest T. In this work, we extend causal inference approaches to… read more here.
Keywords: validate surrogate; potential outcomes; surrogate; incorporating baseline ... See more keywords
Using a surrogate with heterogeneous utility to test for a treatment effect
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9602
Abstract: The primary benefit of identifying a valid surrogate marker is the ability to use it in a future trial to test for a treatment effect with shorter follow‐up time or less cost. However, previous work… read more here.
Keywords: test treatment; treatment effect; surrogate; test ... See more keywords
Efficient aerodynamic shape optimization of transonic wings using a parallel infilling strategy and surrogate models
Sign Up to like & getrecommendations! Published in 2017 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-016-1546-7
Abstract: Surrogate models are used to dramatically improve the design efficiency of numerical aerodynamic shape optimization, where high-fidelity, expensive computational fluid dynamics (CFD) is often employed. Traditionally, in adaptation, only one single sample point is chosen… read more here.
Keywords: shape optimization; optimization transonic; surrogate; optimization ... See more keywords
Constraint aggregation for large number of constraints in wing surrogate-based optimization
Sign Up to like & getrecommendations! Published in 2019 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-018-2074-4
Abstract: The method of aggregating a large number of constraints into one or few constraints has been successfully applied to wing structural design using gradient-based local optimization. However, numerical difficulties may occur in the case that… read more here.
Keywords: constraint aggregation; surrogate; large number; optimization ... See more keywords
A dynamic surrogate-assisted evolutionary algorithm framework for expensive structural optimization
Sign Up to like & getrecommendations! Published in 2019 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-019-02391-8
Abstract: In the expensive structural optimization, the data-driven surrogate model has been proven to be an effective alternative to physical simulation (or experiment). However, the static surrogate-assisted evolutionary algorithm (SAEA) often becomes powerless and inefficient when… read more here.
Keywords: evolutionary algorithm; framework; surrogate; optimization ... See more keywords
Diagnostic value of surrogate CSF biomarkers for Creutzfeldt–Jakob disease in the era of RT-QuIC
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09537-0
Abstract: Prion real-time quaking-induced conversion (RT-QuIC) is emerging as the most potent assay for the in vivo diagnosis of Creutzfeldt–Jakob disease (CJD), but its full application, especially as a screening test, is limited by suboptimal substrate… read more here.
Keywords: diagnosis; surrogate; csf; jakob disease ... See more keywords
Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05378-7
Abstract: Oestrogen receptor-positive (ER+) and human epidermal receptor 2-negative (HER2–) breast cancers are classified as Luminal A or B based on gene expression, but immunohistochemical markers are used for surrogate subtyping. The aims of this study… read more here.
Keywords: agreement; breast; surrogate; breast cancer ... See more keywords