Assessment of Progression-Free Survival as a Surrogate End Point of Overall Survival in First-Line Treatment of Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.18939
Abstract: This systematic review and meta-analysis evaluates whether progression-free survival is a validated surrogate end point for overall survival in patients with advanced ovarian cancer. read more here.
Keywords: end point; free survival; point overall; surrogate end ... See more keywords
Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non–Small Cell Lung or Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.17547
Abstract: Key Points Question What surrogate end point for capturing worsening disease is most correlated with overall survival (OS) in large linked clinicogenomic data sets? Findings In this cohort study of patients with non–small cell lung… read more here.
Keywords: overall survival; end; patients non; non small ... See more keywords
Assessment of Surrogate End Point Trends in Clinical Trials to Approve Oncology Drugs From 2001 to 2020 in Japan
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.8875
Abstract: Key Points Question How often are surrogate end points used to support the approval of anticancer drugs, and are confirmatory studies that use overall survival as an end point conducted in Japan? Findings In this… read more here.
Keywords: oncology; end point; surrogate end; end points ... See more keywords
The Use of Modified Surrogate End Points in Cancer Clinical Trials
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Investigation"
DOI: 10.1080/07357907.2021.2006683
Abstract: The use of various surrogate end points in cancer clinical trials is erupting. Such measures reflect the efficacy of a studied intervention and may form the basis of a future approval by the United States… read more here.
Keywords: cancer; surrogate end; end points; pfs ... See more keywords
Surrogate end points for overall survival in patients with advanced non-small-cell lung cancer in trials of immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14122
Abstract: e14122 Background: Our objective was to evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate end points for overall survival (OS) among patients with advanced non-small-cell lung cancer (NSCLC) in randomized trials of… read more here.
Keywords: end points; surrogate end; trials immunotherapy; pfs ... See more keywords