Trials & Tribulations of Liver Transplantation‐ are trials now prohibitive without surrogate endpoints?
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DOI: 10.1002/lt.25988
Abstract: During the past 5 decades, liver transplantation has moved from its pioneering days where success was measured in days to a point where it is viewed as a routine part of medical care. Despite this… read more here.
Keywords: surrogate endpoints; tribulations liver; transplantation trials; trials tribulations ... See more keywords
Response‐Adaptive Randomization Procedure in Clinical Trials with Surrogate Endpoints
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DOI: 10.1002/sim.10286
Abstract: In clinical trials, subjects are usually recruited sequentially. According to the outcomes amassed thus far in a trial, the response‐adaptive randomization (RAR) design has been shown to be an advantageous treatment assignment procedure that skews… read more here.
Keywords: adaptive randomization; response adaptive; procedure; surrogate endpoints ... See more keywords
Validation of surrogate endpoints in cancer clinical trials via principal stratification with an application to a prostate cancer trial.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7318
Abstract: Increasing attention has been focused on the use and validation of surrogate endpoints in cancer clinical trials. Previous literature on validation of surrogate endpoints are classified into four approaches: the proportion explained approach; the indirect… read more here.
Keywords: surrogate endpoints; surrogate; endpoints cancer; validation surrogate ... See more keywords
Association Between Surrogate Endpoints and Clinical Outcomes in Immunoglobulin A Nephropathy: A Systematic Literature Review
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DOI: 10.1007/s12325-025-03331-3
Abstract: At least 50% of patients with immunoglobulin A nephropathy (IgAN) reach kidney failure within 12 years of diagnosis. Delayed progression to kidney failure remains the gold standard treatment endpoint in IgAN, but the prolonged time… read more here.
Keywords: surrogate endpoints; long term; literature; kidney ... See more keywords
Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00481-y
Abstract: In response to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, over 200 vaccine candidates against coronavirus disease 2019 (COVID-2019) are under development and currently moving forward at an unparalleled speed. The availability of surrogate… read more here.
Keywords: covid 2019; surrogate endpoints; correlates protection; evidence ... See more keywords
Correlation between surrogate endpoints and overall survival in unresectable hepatocellular carcinoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
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DOI: 10.1038/s41598-024-54945-6
Abstract: This study aimed to assess the therapeutic effect of immune checkpoint inhibitors (ICIs) in patients with unresectable hepatocellular carcinoma (uHCC) and investigate the correlation between surrogate endpoints and overall survival (OS). A systematic literature search… read more here.
Keywords: survival; correlation; immune checkpoint; surrogate endpoints ... See more keywords
Correlates of protection for inactivated enterovirus 71 vaccine: the analysis of immunological surrogate endpoints
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2017.1335603
Abstract: ABSTRACT Background: Inactivated Enterovirus 71 (EV71) vaccines showed significant efficacy against the diseases associated with EV71 and a neutralizing antibody (NTAb) titer of 1:16–1:32 was suggested as the correlates of the vaccine protection. This paper… read more here.
Keywords: protection; surrogate endpoints; inactivated enterovirus; vaccine ... See more keywords
Patient-reported outcome measures should not be the primary outcome in glaucoma clinical trials of disease modification
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Ophthalmology"
DOI: 10.1136/bjo-2021-320722
Abstract: In the 19th century, Sir William Osler, one of the fathers of modern medicine, stated that ‘The good physician treats the disease; the great physician treats the patient who has the disease’, indicating that, as… read more here.
Keywords: surrogate endpoints; glaucoma; outcome; endpoint ... See more keywords
Surrogate endpoints in global health research: still searching for killer apps and silver bullets?
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DOI: 10.1136/bmjgh-2018-000755
Abstract: In clinical research, there is widespread acceptance that surrogate endpoints may not translate to long-term benefits.1–3 Clinical epidemiologists highlight the hazards of surrogate measures (eg, biomarkers, laboratory test results and short-term improvements in health) that… read more here.
Keywords: surrogate endpoints; health research; endpoints global; health ... See more keywords
Need for better reporting of trials with surrogate endpoints: SPIRIT|CONSORT-SURROGATE extensions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Epidemiology and Community Health"
DOI: 10.1136/jech-2022-219294
Abstract: Evidence for the effectiveness of health interventions should ideally come from randomised trials that assess a participant relevant final outcome (PRFO), such as health status or survival. 2 However, such trials often require large sample… read more here.
Keywords: surrogate endpoints; health; randomised trials; reporting trials ... See more keywords
Abstract 827: Correlation among early surrogate endpoints and survival in borderline-resectable pancreatic cancer: A trial-level meta-analysis
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-827
Abstract: Multiple endpoints are used as surrogates for overall survival (OS) in clinical trials for borderline resectable pancreatic cancer (BRPC), including the R0 resection rate. However, consensus is lacking regarding the validity of this and other… read more here.
Keywords: cancer; correlation; borderline resectable; resectable pancreatic ... See more keywords