Identifying surrogate markers in real‐world comparative effectiveness research
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9569
Abstract: In comparative effectiveness research (CER), leveraging short‐term surrogates to infer treatment effects on long‐term outcomes can guide policymakers evaluating new treatments. Numerous statistical procedures for identifying surrogates have been proposed for randomized clinical trials (RCTs),… read more here.
Keywords: surrogate markers; effectiveness research; real world; comparative effectiveness ... See more keywords
An internet-based approach for lifestyle changes in patients with NAFLD: Two-year effects on weight loss and surrogate markers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.07.013
Abstract: BACKGROUND & AIMS Interventions aimed at lifestyle changes are pivotal for the treatment of non-alcoholic fatty liver disease (NAFLD), and web-based programs might help remove barriers in both patients and therapists. METHODS In the period… read more here.
Keywords: intervention; surrogate markers; lifestyle changes; weight loss ... See more keywords
Surrogate markers for high-risk human papillomavirus infection in oral epithelial dysplasia: A comparison of p16, Ki-67, and ProExC.
Sign Up to like & getrecommendations! Published in 2019 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2019.09.019
Abstract: OBJECTIVE The aim of this study was to determine the utility of surrogate markers of human papillomavirus (HPV) infection in the diagnosis of HPV-associated oral epithelial dysplasia (OED). STUDY DESIGN Twelve cases of oral dysplasia… read more here.
Keywords: epithelial dysplasia; p16; infection; surrogate markers ... See more keywords
Surrogate markers for hepatitis B Virus covalently closed circular DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in liver disease"
DOI: 10.1055/a-1830-2741
Abstract: Chronic infection with the Hepatitis B virus (HBV) is one of the most common causes of liver disease worldwide. Chronic HBV infection is currently incurable because of the persistence of the viral template for the… read more here.
Keywords: markers hepatitis; surrogate markers; hepatitis virus; covalently closed ... See more keywords
The effect of levothyroxine treatment in individuals with subclinical hypothyroidism on surrogate markers of atherosclerosis: a meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Community Hospital Internal Medicine Perspectives"
DOI: 10.1080/20009666.2019.1625704
Abstract: ABSTRACT Introduction: Subclinical hypothyroidism is associated with increased carotid intima media thickness (CIMT) and decreased flow-mediated dilation (FMD) – surrogate markers of subclinical atherosclerotic cardiovascular disease (ASCVD). However, treatment with levothyroxine in this population remains… read more here.
Keywords: subclinical hypothyroidism; hypothyroidism; hypothyroidism surrogate; treatment ... See more keywords
FDA's dilemma with the aducanumab approval: public pressure and hope, surrogate markers and efficacy, and possible next steps.
Sign Up to like & getrecommendations! Published in 2022 at "BMJ evidence-based medicine"
DOI: 10.1136/bmjebm-2022-111914
Abstract: Accelerating Food and Drug Administration (FDA) product approval to market based on surrogate markers in the absence of proven efficacy creates a risk of adverse outcomes for affected patients, even in response to a life-threatening… read more here.
Keywords: dilemma aducanumab; approval public; surrogate markers; approval ... See more keywords
A Comparison of the Commonly Used Surrogate Markers for Citrate Accumulation and Toxicity during Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation
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DOI: 10.1159/000524129
Abstract: Introduction: Continuous renal replacement therapy using regional citrate anticoagulation is commonly used as a modality of organ support in the critically ill population. Currently, citrate accumulation or toxicity is assessed using surrogate markers, notably the… read more here.
Keywords: surrogate markers; citrate accumulation; citrate; accumulation toxicity ... See more keywords
A high-throughput screening RT-qPCR assay for quantifying surrogate markers of immunity from PBMCs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.962220
Abstract: Immunoassays that quantitate cytokines and other surrogate markers of immunity from peripheral blood mononuclear cells (PBMCs), such as flow cytometry or Enzyme-Linked Immunosorbent Spot (ELIspot), allow highly sensitive measurements of immune effector function. However, those… read more here.
Keywords: markers immunity; screening qpcr; throughput screening; surrogate markers ... See more keywords
Short-term weight-mediated effects of sleeve gastrectomy on echocardiographic surrogate markers of atherosclerotic vascular disease.
Sign Up to like & getrecommendations! Published in 2020 at "Kardiologia polska"
DOI: 10.33963/kp.15560
Abstract: 655 In this issue of Kardiologia Polska (Kardiol Pol, Polish Heart Journal), Kaya et al7 illustrated the re sults of their prospective study including 71 pa tients affected by morbid obesity undergoing LSG, with the… read more here.
Keywords: term; vascular disease; disease; surrogate markers ... See more keywords
Are surrogate markers for diabetic foot osteomyelitis remission reliable?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Podiatric Medical Association"
DOI: 10.7547/20-147
Abstract: BACKGROUND The aim of this study was to evaluate surrogate markers commonly used in the literature for diabetic foot osteomyelitis remission after initial treatment for diabetic foot infections. METHODS Thirty-five patients with diabetic foot infections… read more here.
Keywords: surrogate markers; diabetic foot; osteomyelitis; remission ... See more keywords