What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?
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DOI: 10.1038/s41418-022-00987-0
Abstract: In many human cancers the control of apoptosis is dysregulated, for instance as a result of the overexpression of pro-survival BCL-2 proteins. This promotes tumorigenesis by protecting nascent neoplastic cells from stress and renders malignant… read more here.
Keywords: bh3 mimetic; survival bcl; bcl; bcl proteins ... See more keywords