Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro.
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DOI: 10.1016/j.biomaterials.2021.120700
Abstract: Neurons derived from human induced pluripotent stem cells (hiPSCs) are powerful tools for modeling neural pathophysiology and preclinical efficacy/toxicity screening of novel therapeutic compounds. However, human neurons cultured in vitro typically do not fully recapitulate… read more here.
Keywords: extracellular vesicles; derived extracellular; survival electrophysiological; function ... See more keywords