General Population Mortality Adjustment in Survival Extrapolation of Cancer Trials: Exploring Plausibility and Implications for Cost-Effectiveness Analyses in HER2-Positive Breast Cancer in Sweden
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DOI: 10.1177/0272989x241275969
Abstract: Background In economic evaluations of novel therapies, assessing lifetime effects based on trial data often necessitates survival extrapolation, with the choice of model affecting outcomes. The aim of this study was to assess accuracy and… read more here.
Keywords: cancer; breast cancer; mortality; model ... See more keywords
The Acceptance of Overall Survival Extrapolation Methods in Solid Tumor Treatments by Health Technology Assessment Agencies in England, France, and Australia between 2017 and 2022
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DOI: 10.1177/0272989x251351635
Abstract: Background Survival extrapolation is used to predict patients’ overall survival beyond clinical trial follow-up. It can significantly affect the results of a cost-effectiveness analysis and subsequent pricing and reimbursement decisions. However, selecting an appropriate model… read more here.
Keywords: extrapolation; survival extrapolation; acceptance; overall survival ... See more keywords