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Published in 2022 at "Glia"
DOI: 10.1002/glia.24177
Abstract: Survival motor neuron (SMN) protein deficiency results in loss of alpha motor neurons and subsequent muscle atrophy in patients with spinal muscular atrophy (SMA). Reactive microglia have been reported in SMA mice and depleting microglia…
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Keywords:
survival motor;
protein deficiency;
sma;
motor ... See more keywords
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Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00070g
Abstract: G quadruplex structures have been predicted by bioinformatics to form in the 5'- and 3'-untranslated regions (UTRs) of several thousand mature mRNAs and are believed to play a role in translation regulation. Elucidation of these…
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Keywords:
protein;
structure within;
quadruplex structure;
survival motor ... See more keywords
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3
Published in 2023 at "Biology"
DOI: 10.3390/biology12010132
Abstract: Simple Summary Neural stem cells (NSCs) are used for developing cellular replacement strategies for motor neuron diseases. However, this approach has been limited by poor survival and the insufficient function of NSC-derived motor neurons. Seeking…
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Keywords:
motor neurons;
survival motor;
neural stem;
motor ... See more keywords
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Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21030794
Abstract: The defective human survival motor neuron 1 (SMN1) gene leads to spinal muscular atrophy (SMA), the most common genetic cause of infant mortality. We previously reported that loss of SMN results in rapid differentiation of…
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Keywords:
survival motor;
smn;
motor neuron;
germ cell ... See more keywords