Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.05.475126
Abstract: Microglia serve critical remodeling roles that shape the developing nervous system, responding to the changing neural environment with phagocytosis or soluble factor secretion. Recent single-cell sequencing (scRNAseq) studies have revealed the context-dependent diversity in microglial… read more here.
Keywords: survival pathway; apoptotic neurons; expression; neuronal apoptosis ... See more keywords
Abstract 3674: Differential expression of stress-survival pathway genes related to Hispanic colorectal cancer disparities
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/1538-7445.am2022-3674
Abstract: Colorectal cancer (CRC) accounts for 12% and 8% of all estimated new cases of cancer and 11% and 9% of all cancer deaths in Hispanic men and women, respectively. Stress-survival pathways have been implicated in… read more here.
Keywords: survival pathway; expression; crc; cancer ... See more keywords
Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.27330
Abstract: The alkylating agent platinum is first-line chemotherapy treatment for high-grade serous carcinomas (HGSC) of tubal-ovarian origin. Platinum compounds cause DNA damage and induce apoptotic cell death in the bulk tumor population. However, subpopulations of tumor… read more here.
Keywords: platinum; death; line; survival pathway ... See more keywords