New strategies to treat AML: novel insights into AML survival pathways and combination therapies
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-01069-1
Abstract: The effective treatment of acute myeloid leukemia (AML) is very challenging. Due to the immense heterogeneity of this disease, treating it using a “one size fits all” approach is ineffective and only benefits a subset… read more here.
Keywords: combination; new strategies; novel insights; aml survival ... See more keywords
Cell survival pathways targeted in rare lung disease affecting women
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adi1215
Abstract: Novel drug targets are identified in lymphangioleiomyomatosis (LAM), a rare disease in women. These targets focus on uterine transcription factors necessary for LAM cell survival. read more here.
Keywords: rare lung; disease; targeted rare; pathways targeted ... See more keywords
Overexpression and Targeted Activation of the Protein Phosphatases SHP-1 Abrogates Survival Pathways in Large Granular Lymphocyte Leukemia (LGLL)
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-129883
Abstract: Introduction: Aberrant phosphorylation-mediated signaling is a well-established condition involved in the onset and progression of virtually all types of cancer. That not only depends on the over-activation of protein kinases, but also on the lack… read more here.
Keywords: activity; activation protein; activation; survival pathways ... See more keywords
Oleil Hydroxytyrosol (HTOL) Exerts Anti-Myeloma Activity by Antagonizing Key Survival Pathways in Malignant Plasma Cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111639
Abstract: Polyphenols from olive oil are endowed with several biological activities. Chemical modifications have been recently applied to these compounds to improve their therapeutic activity in different pathological settings, including cancer. Herein, we describe the in… read more here.
Keywords: hydroxytyrosol htol; oleil hydroxytyrosol; survival pathways; htol ... See more keywords