GABAB receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery.
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DOI: 10.1016/j.carbpol.2017.09.075
Abstract: The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis of lung tumor has been attracted more interest. GABAB receptor ligand-directed nanoparticles consisting of baclofen functionalized trimethyl chitosan (Bac-TMC) as polymeric… read more here.
Keywords: delivery; survivin sirna; receptor; ligand ... See more keywords
Anti-HER2 functionalized graphene oxide as survivin-siRNA delivery carrier inhibits breast carcinoma growth in vitro and in vivo
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DOI: 10.2147/dddt.s169430
Abstract: Background The success of gene therapy is mostly dependent on the development of gene carrier. Graphene oxide (GO) possesses excellent aqueous solubility and biocompatibility, which is important for its biochemical and medical applications. Our previous… read more here.
Keywords: sirna delivery; survivin; anti her2; carrier ... See more keywords
Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy
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DOI: 10.2147/ijn.s173279
Abstract: Purpose A liposome-based siRNA–drug combination was evaluated as a potential therapeutic strategy to improve the curative effect. Methods A topoisomerase inhibitor SN38 prodrug was combined with a survivin siRNA through codelivery using transferrin (Tf)-L-SN38/P/siRNA. In… read more here.
Keywords: sn38; codelivery sn38; sn38 sirna; survivin sirna ... See more keywords