Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei
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DOI: 10.1128/aac.02484-19
Abstract: As resistance to artemisinins (current frontline drugs in malaria treatment) emerges in Southeast Asia, there is an urgent need to identify the genetic determinants and understand the molecular mechanisms underpinning such resistance. Such insights could… read more here.
Keywords: mutations ubiquitin; susceptibility; southeast asia; resistance ... See more keywords