Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets
Sign Up to like & getrecommendations! Published in 2019 at "Nature Microbiology"
DOI: 10.1038/s41564-019-0609-0
Abstract: Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and… read more here.
Keywords: respiratory droplets; japanese patients; isolated japanese; susceptibility baloxavir ... See more keywords
Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019
Sign Up to like & getrecommendations! Published in 2019 at "Eurosurveillance"
DOI: 10.2807/1560-7917.es.2019.24.12.1900170
Abstract: In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited… read more here.
Keywords: reduced susceptibility; h3n2; january 2019; baloxavir ... See more keywords