Genome‐wide meta‐analysis identifies susceptibility loci for autoimmune hepatitis type 1
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32417
Abstract: Autoimmune hepatitis (AIH) is a rare and chronic autoimmune liver disease. While genetic factors are believed to play a crucial role in the etiopathogenesis of AIH, our understanding of these genetic risk factors is still… read more here.
Keywords: wide meta; autoimmune hepatitis; susceptibility loci; genome wide ... See more keywords
Prenatal diagnosis of susceptibility loci for neurodevelopmental disorders – genetic counseling and pregnancy outcome in 57 cases
Sign Up to like & getrecommendations! Published in 2017 at "Prenatal Diagnosis"
DOI: 10.1002/pd.4979
Abstract: Whole genome array testing not only provides an increased diagnostic yield of pathogenic causative findings, but it may also reveal so called susceptibility loci (SL) for neurodevelopmental disorders. The goal of this study was to… read more here.
Keywords: pregnancy; prenatal diagnosis; susceptibility loci; loci neurodevelopmental ... See more keywords
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3826
Abstract: To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for… read more here.
Keywords: susceptibility; susceptibility loci; different histotypes; ovarian cancer ... See more keywords
Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09517-2
Abstract: Anthracycline-based chemotherapy is associated with dose-dependent, irreversible damage to the heart. Childhood cancer survivors with hypertension after anthracycline exposure are at increased risk of cardiotoxicity, leading to the hypothesis that genetic susceptibility loci for hypertension… read more here.
Keywords: susceptibility; hypertension susceptibility; cancer survivors; susceptibility loci ... See more keywords
Genome-wide association study of actinic keratosis identifies new susceptibility loci implicated in pigmentation and immune regulation pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03301-3
Abstract: Actinic keratosis (AK) is a common precancerous cutaneous neoplasm that arises on chronically sun-exposed skin. AK susceptibility has a moderate genetic component, and although a few susceptibility loci have been identified, including IRF4, TYR, and… read more here.
Keywords: actinic keratosis; susceptibility; susceptibility loci; genome wide ... See more keywords
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci
Sign Up to like & getrecommendations! Published in 2017 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehx213
Abstract: Aims Some genetic susceptibility loci for atrial fibrillation (AF) identified by genome-wide association studies (GWAS) in a European database showed ethnic differences in the Asian population. We explored novel AF susceptibility variants for patients with… read more here.
Keywords: atrial fibrillation; fibrillation; early onset; association ... See more keywords
Genome‐wide meta‐analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy306
Abstract: &NA; Adolescent idiopathic scoliosis (AIS) is the most common musculoskeletal disorder of childhood development. The genetic architecture of AIS is complex, and the great majority of risk factors are undiscovered. To identify new AIS susceptibility… read more here.
Keywords: genome wide; idiopathic scoliosis; analysis; adolescent idiopathic ... See more keywords
A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.03.06.22271725
Abstract: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common forms of skin cancer. There is genetic overlap between skin cancers, pigmentation traits, and autoimmune diseases. We use linkage disequilibrium score regression… read more here.
Keywords: cell carcinoma; cell; squamous cell; basal cell ... See more keywords
Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes
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DOI: 10.1111/jdi.12546
Abstract: Previous studies have suggested a possible relationship between type 2 diabetes mellitus susceptibility loci and diabetic complications. The present study aimed to investigate the associations between type 2 diabetes mellitus loci with peripheral nerve function… read more here.
Keywords: nerve function; susceptibility loci; type diabetes; loci peripheral ... See more keywords
THU0022 Analysis of 47 non-mhc ankylosing spondylitis susceptibility loci reveals shared associated variants across caucasians and chinese han
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6219
Abstract: Background Genetic factors play a prominent role in AS pathogenesis. So far over 40 non-MHC Ankylosing Spondylitis(AS) susceptibility loci with genome-wide or suggestive significance have been initially reported in Caucasians, however, lack of association evidence… read more here.
Keywords: non mhc; susceptibility loci; analysis; chinese han ... See more keywords
Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-219065
Abstract: Objectives Nearly 110 susceptibility loci for rheumatoid arthritis (RA) with modest effect sizes have been identified by population-based genetic association studies, suggesting a large number of undiscovered variants behind a highly polygenic genetic architecture of… read more here.
Keywords: susceptibility loci; biology; rheumatoid arthritis; meta analysis ... See more keywords