Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-017-1394-1
Abstract: Chronic kidney disease and hyperuricemia are serious global health problems. Recent genome-wide association studies have identified various genetic variants related to these disorders. However, most studies have been conducted in a cross-sectional manner. To identify… read more here.
Keywords: locus hyperuricemia; susceptibility; susceptibility locus; novel susceptibility ... See more keywords
A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.073
Abstract: Cultured pluripotent cells accumulate detrimental chromatin alterations, including DNA methylation changes at imprinted genes known as loss of imprinting (LOI). Although the occurrence of LOI is considered a stochastic phenomenon, here we document a genetic… read more here.
Keywords: susceptibility locus; mouse pluripotent; pluripotent cells; chromosome ... See more keywords
Alzheimer’s disease susceptibility locus in CD2AP is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136419
Abstract: INTRODUCTION Rs9296559 within CD2-associated protein (CD2AP) has been identified as a susceptibility locus for Alzheimer's disease (AD). Recent studies indicated that CD2AP functioned as a regulator of endocytic trafficking to modulate the β-amyloid (Aβ) generation… read more here.
Keywords: cd2ap; tau; susceptibility locus; tau levels ... See more keywords