Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway
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DOI: 10.1371/journal.pgen.1006872
Abstract: Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is… read more here.
Keywords: susceptibility; hif binding; cancer; susceptibility polymorphisms ... See more keywords