Abstract 5737: Preclinical study of a novel long-acting receptor-biased rhIL-2 drug with sustained activation of cytotoxic T cells
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DOI: 10.1158/1538-7445.am2025-5737
Abstract: Human Interlukin-2 (hIL-2) targets at malignant tumors, such as renal cell carcinoma and melanoma, and has been on the market for many years. Due to its adverse effects, hIL-2 is limited in clinical use. However,… read more here.
Keywords: long acting; drug sustained; sustained activation; novel long ... See more keywords
Sustained Activation of CLR/RAMP Receptors by Gel-Forming Agonists
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DOI: 10.3390/ijms232113408
Abstract: Background: Adrenomedullin (ADM), adrenomedullin 2 (ADM2), and CGRP family peptides are important regulators of vascular vasotone and integrity, neurotransmission, and fetoplacental development. These peptides signal through CLR/RAMP1, 2, and 3 receptors, and protect against endothelial… read more here.
Keywords: activation clr; gel forming; sustained activation; clr ramp ... See more keywords