Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1143-4
Abstract: Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic… read more here.
Keywords: rapid sustained; like effects; sustained antidepressant; antidepressant like ... See more keywords
Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2020.172913
Abstract: At sub-anaesthetic doses, ketamine, a non competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant (AD) efficacy in patients with treatment-resistant depression (TRD). However, its mechanism of action of ketamine is not fully… read more here.
Keywords: like activity; mpfc; activity ketamine; sustained antidepressant ... See more keywords