Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.06.001
Abstract: Despite great potential, delivery remains as the most significant barrier to the widespread use of siRNA therapeutics. siRNA has delivery limitations due to susceptibility to RNase degradation, low cellular uptake, and poor tissue-specific localization. Here,… read more here.
Keywords: delivery; fracture healing; sustained delivery; sirna nps ... See more keywords
Hydrogels for sustained delivery of biologics to the back of the eye.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.037
Abstract: Hydrogels are water-laden polymer networks that have been used for myriad biological applications. By controlling the chemistry through which a hydrogel is constructed, a wide range of chemical and physical properties can be accessed, making… read more here.
Keywords: delivery; chemistry; delivery biologics; biologics back ... See more keywords
Sustained delivery of siRNA poly- and lipopolyplexes from porous macromer-crosslinked gelatin gels.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.065
Abstract: RNA interference (RNAi) is a promising technique to treat severe diseases on a pre-protein level. We and others postulate that the release of nanoparticle-complexed small interfering RNA (siRNA) from implanted biomaterials could provide structural support… read more here.
Keywords: poly lipopolyplexes; pei; sustained delivery; sirna ... See more keywords
Temperature and pH-sensitive injectable hydrogels based on poly(sulfamethazine carbonate urethane) for sustained delivery of cationic proteins
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DOI: 10.1016/j.polymer.2016.12.039
Abstract: Abstract In recent years, protein therapeutics plays a promising role in the field of medicine. However, intrinsic properties of proteins, including short plasma half-life and hydrolytic stability in vivo, are severely limits their application. To surmount… read more here.
Keywords: peg psmcu; cationic proteins; psmcu; sustained delivery ... See more keywords
SUN-203 Histopathological Evaluation of Prostatic Tissue upon Long Term Sustained Delivery of Diazole
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sun-203
Abstract: Abstract The objective of this study was to quantitatively evaluate the possible morphological alterations that occur in the columnar epithelial cells of the prostate peripheral zone during early development of benign prostatic hyperplasia (BPH). In… read more here.
Keywords: sun 203; sustained delivery; compared controls; delivery ... See more keywords