SUV39H2 is a vulnerability in glioblastoma stem cells enhanced by co-targeting SUV39H1.
Sign Up to like & getrecommendations! Published in 2025 at "Epigenomics"
DOI: 10.1080/17501911.2025.2568366
Abstract: AIM To investigate the role of SUV39H2 in glioblastoma (GBM) stem cells (GSCs) and assess whether co-targeting SUV39H2 and SUV39H1 more effectively disrupts GSC maintenance, offering a potential strategy to improve GBM treatment. METHODS Single-cell… read more here.
Keywords: suv39h1; glioblastoma; gbm; stem cells ... See more keywords
The histone methyltransferase Suv39h regulates 3T3-L1 adipogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Adipocyte"
DOI: 10.1080/21623945.2020.1795422
Abstract: ABSTRACT We discovered a unique expression pattern of two histone methyltransferases Suv39h1 and Suv39h2 during 3T3-L1 adipogenesis, both of which preferentially catalyse the formation of H3K9 dimethylation (H3K9me2) and further H3K9 trimethylation (H3K9me3), a transcriptional… read more here.
Keywords: methyltransferase; adipogenesis; expression; suv39h1 ... See more keywords
Downâregulation of Suv39h1 attenuates neointima formation after carotid artery injury in diabetic rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14809
Abstract: Patients with diabetes have an increased risk of vascular complications. Suv39h1, a histone methyltransferase, plays a protective role against myocardial injury in diabetes. Herein, we intend to explore whether Suv39h1 could affect neointimal formation after… read more here.
Keywords: carotid artery; injury diabetic; formation; suv39h1 ... See more keywords
Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis
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DOI: 10.1136/gutjnl-2023-329671
Abstract: Objective Liver fibrosis is a prelude to a host of end-stage liver diseases. Hepatic stellate cells (HSCs), switching from a quiescent state to myofibroblasts, are the major source for excessive production of extracellular matrix proteins.… read more here.
Keywords: myofibroblast transition; fibrosis; suv39h1; liver fibrosis ... See more keywords
SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "JCI Insight"
DOI: 10.1172/jci.insight.186344
Abstract: Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse and improving outcomes. We identify SUV39H1, a… read more here.
Keywords: cancer; stem cell; suv39h1; gbm ... See more keywords
MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Pain"
DOI: 10.1177/17448069251389416
Abstract: The downregulation of mu-opioid receptor (MOR) expression in dorsal root ganglia (DRG) following peripheral nerve injury plays a pivotal role in neuropathic pain development and contributes to the reduced efficacy of morphine analgesia. The molecular… read more here.
Keywords: transcriptional silencing; suv39h1; mbd1; injury ... See more keywords
SUV39H1-Mediated DNMT1 is Participated in the Epigenetic Regulation of Smad3 in Cervical Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200721110016
Abstract: BACKGROUND Smad3 is a pivotal intracellular mediator for participating in the activation of multiple immune signal pathway. OBJECTIVE The epigenetic regulation mechanism of the positive immune factor Smad3 in cervical cancer remains unknown. Therefore, the… read more here.
Keywords: cervical cancer; smad3; expression; suv39h1 ... See more keywords