Brain amyloid PET interpretation approaches: from visual assessment in the clinic to quantitative pharmacokinetic modeling
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Translational Imaging"
DOI: 10.1007/s40336-017-0257-4
Abstract: PurposeCerebral β-amyloid burden can be measured by positron emission tomography (PET) tracers, including 11C-Pittsburgh Compound B (11C-PiB) and three fluorinated tracers that have been approved by regulatory agencies. This review focuses on the current clinical… read more here.
Keywords: pharmacokinetic modeling; interpretation; 11c pib; amyloid pet ... See more keywords
A simulation study on the impact of the blood flow-dependent component in [18F]AV45 SUVR in Alzheimer’s disease
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DOI: 10.1371/journal.pone.0189155
Abstract: Background Increased brain uptake on [18F]AV45 PET is a biomarker for Alzheimer’s disease (AD). The standardised uptake value ratio (SUVR) is widely used for quantification but is subject to variability. Here we evaluate how SUVR… read more here.
Keywords: blood flow; reference; 18f av45; suvr ... See more keywords
Longitudinal Tau PET Using 18F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters
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DOI: 10.2967/jnumed.122.263926
Abstract: Visual Abstract Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, such as practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow,… read more here.
Keywords: cerebral blood; suvr; pet; blood flow ... See more keywords