Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-κB pathways in vitro
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DOI: 10.1080/21655979.2021.2024685
Abstract: ABSTRACT Osteoarthritis (OA), an inflammatory response in chondrocytes, leads to extracellular matrix (ECM) degradation and cartilage destruction. Timosaponin B-II (TB-II) is the main bioactive component of Rhizoma Anemarrhenae with reported antioxidant and anti-inflammatory effects. This… read more here.
Keywords: matrix; extracellular matrix; inflammation; ecm degradation ... See more keywords
BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner
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DOI: 10.1371/journal.pone.0263430
Abstract: BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an inhibitor… read more here.
Keywords: transcription; bmp7; sw1353 cells; 47s gene ... See more keywords
Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells
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DOI: 10.3390/nu14204277
Abstract: Previous studies have demonstrated the anticancer activities of tocotrienol on several types of cancer, but its effects on chondrosarcoma have never been investigated. Therefore, this study aims to determine the anticancer properties of annatto tocotrienol… read more here.
Keywords: sw1353 cells; analysis; chondrosarcoma; anticancer ... See more keywords
Temporal profiling with ultra-deep RRBS sequencing reveals the relative rarity of stably maintained methylated CpG sites in human cells
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DOI: 10.3724/abbs.2022185
Abstract: ARPE-19 cells, SW1353 cells and Jurkat cells were purchased from the Cell Bank (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China). ARPE-19 and SW1353 cells were cultured with DMEM/F-12 medium (Biological Industries,… read more here.
Keywords: temporal profiling; dna; profiling ultra; ultra deep ... See more keywords