The Forced Swim Test for Depression-Like Behavior in Rodents.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8994-2_5
Abstract: The forced swim test assesses learned helplessness, which is a feature of depression-like behavior in rodents. This test has also been used in testing the efficacy of existing and novel antidepressant drugs. It is based… read more here.
Keywords: like behavior; forced swim; swim test; test ... See more keywords
Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06118-4
Abstract: Emerging evidence has implicated the endogenous opioid system in mediating ketamine's antidepressant activity in subjects with major depressive disorder. To date, mu opioid receptors have been suggested as the primary opioid receptor of interest. However,… read more here.
Keywords: effects ketamine; kappa opioid; opioid receptors; swim test ... See more keywords
The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental and clinical psychopharmacology"
DOI: 10.1037/pha0000310
Abstract: d-Methadone (dextromethadone) is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist that binds to the dizocilpine (MK-801)-binding site of the receptor with an affinity comparable with that of well-established NMDAR antagonists. Considering the similar NMDAR activity of… read more here.
Keywords: methadone; forced swim; swim test; receptor ... See more keywords
Considerations of Pool Dimensions in the Forced Swim Test in Predicting the Potential Antidepressant Activity of Drugs
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2021.757348
Abstract: The forced swim test (FST) was proposed by Porsolt et al. (1977a,b) as a relatively rapid test to identify new compounds with potential antidepressant activity in rats and mice. In this test, the total time… read more here.
Keywords: forced swim; immobility; swim test; antidepressant ... See more keywords
Sex Differences in the Effects of a Kappa Opioid Receptor Antagonist in the Forced Swim Test
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00093
Abstract: There is growing evidence that kappa opioid receptor (KOR) antagonists could be a useful class of therapeutics for treating depression and anxiety. However, the overwhelming majority of preclinical investigations examining the behavioral effects of KOR… read more here.
Keywords: opioid receptor; forced swim; swim test; california mice ... See more keywords