An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline
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DOI: 10.1021/acsmedchemlett.2c00166
Abstract: Precision deuteration has become part of the medicinal chemist’s toolbox, but its usefulness can be undermined by unpredictable metabolic switch effects. Herein we report the deuteration of doxophylline, a drug used in the treatment of… read more here.
Keywords: unexpected deuterium; metabolic switch; switch; switch doxophylline ... See more keywords