An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.04.039
Abstract: Ribonucleoprotein enzymes require dynamic conformations of their RNA constituents for regulated catalysis. Human telomerase employs a non-coding RNA (hTR) with a bipartite arrangement of domains-a template-containing core and a distal three-way junction (CR4/5) that stimulates… read more here.
Keywords: telomerase; switch human; catalysis; activity switch ... See more keywords
Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells
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DOI: 10.3390/ijms222111805
Abstract: NAA10 is a major N-terminal acetyltransferase (NAT) that catalyzes the cotranslational N-terminal (Nt-) acetylation of 40% of the human proteome. Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been… read more here.
Keywords: naa10 trp38; switch human; hydroxylation; acetyltransferase ... See more keywords