Articles with "switch region" as a keyword



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Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology

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Published in 2022 at "Brain"

DOI: 10.1093/brain/awac049

Abstract: Abstract RAC1 is a highly conserved Rho GTPase critical for many cellular and developmental processes. De novo missense RAC1 variants cause a highly variable neurodevelopmental disorder. Some of these variants have previously been shown to… read more here.

Keywords: rac1 variants; switch region; rac1; developmental syndrome ... See more keywords
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Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo

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Published in 2018 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.01732-17

Abstract: ABSTRACT Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi. Reports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel antiinfectives against scrub typhus. Corallopyronin… read more here.

Keywords: orientia tsutsugamushi; vivo; tsutsugamushi; rna polymerase ... See more keywords
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Immunoglobulin Class Switch Recombination Is Initiated by Rare Cytosine Deamination Events at Switch Regions

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Published in 2020 at "Molecular and Cellular Biology"

DOI: 10.1128/mcb.00125-20

Abstract: Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) class switch recombination (CSR), somatic hypermutation (SHM), and gene conversion by converting DNA cytosines to uracils at specific genomic regions. In this study, we examined AID footprints across… read more here.

Keywords: switch region; class switch; aid; deamination ... See more keywords