In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.105110
Abstract: KRAS mutation is prevalent in around 30% of all cancers and is an undruggable molecular target. Of seven mutations at codon 12 and 13, only one, the G12C mutant is finally proven to be druggable,… read more here.
Keywords: silico comparative; comparative analysis; gtp; analysis kras ... See more keywords
Guiding a mutator in antibody diversification
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DOI: 10.1038/s41422-018-0085-8
Abstract: Activation Induced Cytidine Deaminase is a mutator that is essential for antibody diversification. A new study, recently reported in Cell Research, provides insights into the mechanism that guides the mutator to physiological targets. The immune… read more here.
Keywords: antibody; aid targets; rod1; aid ... See more keywords