Switchable Chemoselectivity for Organocatalytic, Asymmetric Malononitrile Addition to ortho-Formyl Chalcones.
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DOI: 10.1021/acs.orglett.7b02862
Abstract: Chemoselective 1,2- and 1,4-addition of malononitriles to ortho-formyl chalcones using cinchona alkaloid based bifunctional chiral organocatalysts has been shown by tuning the electronic nature of the malononitriles. Alkyl (hard) malononitriles undergo an asymmetric 1,2-addition followed… read more here.
Keywords: organocatalytic asymmetric; addition; formyl chalcones; chemoselectivity organocatalytic ... See more keywords