Cortisol Detection in Undiluted Human Serum Using a Sensitive Electrochemical Structure-Switching Aptamer over an Antifouling Nanocomposite Layer
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c03552
Abstract: There is a strong and growing need to monitor stress biomarkers in vivo for real-time emotional and wellness assessment. Toward this, we report a reagent-free electrochemical aptasensor with a nanocomposite antifouling layer for sensitive and… read more here.
Keywords: cortisol; detection; switching aptamer; serum ... See more keywords
Switching the aptamer attachment geometry can dramatically alter the signalling and performance of electrochemical aptamer-based sensors.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04557a
Abstract: Electrochemical aptamer-based (EAB) sensors, composed of an electrode-bound DNA aptamer with a redox reporter on the distal end, offer the promise of high-frequency, real-time molecular measurements in complex sample matrices and even in vivo. Here… read more here.
Keywords: switching aptamer; electrochemical aptamer; aptamer based; geometry ... See more keywords
RE-SELEX: restriction enzyme-based evolution of structure-switching aptamer biosensors
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02715h
Abstract: Aptamers are widely employed as recognition elements in small molecule biosensors due to their ability to recognize small molecule targets with high affinity and selectivity. Structure-switching aptamers are particularly promising for biosensing applications because target-induced… read more here.
Keywords: restriction; switching aptamer; evolution; small molecule ... See more keywords