Enhanced β2-microglobulin binding of a "navigator" molecule bearing a single-chain variable fragment antibody for artificial switching of metabolic processing pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm00385b
Abstract: Kidney dysfunction increases the blood levels of β2-microglobulin (β2-m), triggering dialysis-related amyloidosis. Previously, we developed a navigator molecule, consisting of a fusion protein of the N-terminal domain of apolipoprotein E (ApoE NTD) and the α3… read more here.
Keywords: switching metabolic; apoe ntd; navigator; navigator molecule ... See more keywords
Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway
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DOI: 10.7554/elife.23210
Abstract: The transcription factor RpaA is the master regulator of circadian transcription in cyanobacteria, driving genome-wide oscillations in mRNA abundance. Deletion of rpaA has no effect on viability in constant light conditions, but renders cells inviable… read more here.
Keywords: switching metabolic; programs response; output pathway; circadian output ... See more keywords