Regulation of Tak1 alternative splicing by splice-switching oligonucleotides.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.160
Abstract: Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit different tissue distributions and functions. Aberrant protein isoforms can lead to abnormalities in protein function and may even result… read more here.
Keywords: tak1; switching oligonucleotides; splice switching; alternative splicing ... See more keywords
Development of tailored splice-switching oligonucleotides for progressive brain disorders in Europe: development, regulation, and implementation considerations
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079540.122
Abstract: Splice-modulating antisense oligonucleotides (ASOs) offer treatment options for rare neurological diseases, including those with very rare mutations, where patient-specific, individualized ASOs have to be developed. Inspired by the development of milasen, the 1 Mutation 1… read more here.
Keywords: splice switching; splice; development tailored; development ... See more keywords